Aureka Bio is seeking a highly motivated, passionate, and detail-oriented Scientist or Senior Scientist in antibody engineering and biotherapeutics. This is an exciting opportunity to contribute to a fast-growing, AI-driven biotherapeutics company dedicated to rapidly generating next-generation biologics for Immunology & Inflammation (I&I) and metabolic diseases.

This is a hands-on, bench-facing role with ownership over antibody design, engineering, and optimization efforts across multiple programs. The successful candidate will drive the generation of best-in-class biotherapeutics from early discovery through preclinical development, working closely with bioassay, translational biology, and computational teams. The final title and level will be determined based on experience.

Key Responsibilities

·    Design, engineer, and optimize monoclonal and multi-specific antibodies for potency, affinity, stability, developability, and manufacturability

·    Build and screen antibody libraries (yeast display, phage display, or mammalian display)

·    Perform antibody screening assays, including binding kinetics (SPR/BLI), ligand blocking, epitope binning, polyspecificity, thermal stability, developability to rapidly identify and prioritize lead candidates.

·    Collaborate with assay development and translational teams to validate functional activity in relevant in vitro and in vivo systems

·    Interface with CROs and external collaborators to ensure high-quality data generation and timely project execution.

·    Present experimental results and program updates to project teams, senior management, and collaborators.

·    Maintain accurate experimental documentation in ELN and ensure compliance with best data practices.

Required Qualifications

Scientist Level

·    PhD with 1–3 years of relevant industry or MS with 4–6 years of relevant industry experience

Senior Scientist Level

·    PhD with 4–8 years of industry experience or MS with 8–12 years of industry experience

Technical Skills

·    Deep hands-on experience in antibody engineering and protein expression/characterization

·    Proficient in affinity maturation and antibody optimization

·    Strong background with biophysical and biochemical characterization (e.g., BLI, SPR, SEC, DSF)

·    Solid molecular biology skills: cloning, mutagenesis, library construction

·    Experience in yeast display, phage display, or mammalian display technologies will be a plus

·    Experience in vivo efficacy or PK/PD will be a plus.

·    Data-driven approach to experimental design and decision making

Compensation:

Competitive and commensurate with experience, including salary, equity, and benefits—aligned with the company’s long-term success.

Why join us:

·    Competitive compensation, comprehensive healthcare coverage, equity participation, family leave and paid time off

·    A dynamic early-stage work environment and highly interdisciplinary, talented team with a collaborative and innovation-driven culture.

·    Participation in an unprecedented opportunity to significantly impact the quality of life of patients by developing a targeted approach to delivering therapeutic molecules.

·     Professional growth opportunities through mentoring, training, immersion in cross-functional projects, and opportunities to learn and try new things.